I want Dr K to go on another sex rampage. Susan is due her totties soon anyway, and in his grief Karl can shag whoever he hasn't yet in Ramsey Street. I also think they should bring back Harold and have him and Lou set up a protection ring with them going round and smashing up shops and generally giving folk a kicking. Hard up for cash, Steve Parker will grudgingly help.
Zeke will hopefully die in a horrific football to the groin incident whereby he has to get his balls amputated (he might as well anyway for the amount he uses them) but contracts an infection and dies. In his grief Karl can shag whoever he hasn't yet in Ramsey Street.
Rachael leaves to join a white slavery ring after being duped as we all know she is thick as shit. In his grief Karl can shag whoever he hasn't yet in Ramsey Street.
Bridget and Declan will both be killed after Bridget's face implodes in on itself, as it has clearly been threatening to do for a while. At the time she was blowing Declan and he dies from the blood loss of losing his cock. Karl tried to save him but couldn't, and in his grief Karl can shag whoever he hasn't yet in Ramsey Street.