Grasshoppers have been underachieving for years, it feels like. They used to be European fixtures and now they're nowhere. Not quite Servette levels of collapse, mind.
It's true what you're saying, without some level of sponsorship or subsidy (Basel, Sheriff Tiraspol) smaller countries' teams aren't going to go anywhere fast.
For Midtjylland, last 16 in the EL would be a great achievement and although that's a glass ceiling it's a hell of a ride to get there. The trick will be if they can keep it up when the novelty wears off and the fans slowly start to disperse (as seems to have happened with FCK, who now often get lower gates than the older, more-established, but pretty guff neighbors of Brondby.)