Nice set-up.
I think UtN had/has a Focus and rated it very highly. Your bike shares (or shared, in terms of the wheels) a lot of components with my own aluminium framed Cube, which was my first and only road bike.
105 groupset has been superb, requiring very limited maintenance if looked after reasonably carefully. I have the stock Fulcrum 7s that came with my bike, and they've proved bomb-proof. I'm not that bothered about the weight issue as my own bloody weight fluctuates so much it seems immaterial. Also, being a short-arse, my bikes have small frames, so I get the benefit of a few ounces shed in this respect
I'm not in the market for a new bike any time soon, but if I were to take the plunge, I reckon I'd opt for titanium. Light, good damping/flexibility properties (like steel but not so heavy), and pretty damn sexy! Oh, and like steel, if the frame snaps, you can have it repaired, unlike carbon.
Buying a titanium bike is like making love to a beautiful woman....